This firm produced perfins from 1899 to 1917.
Here are two Johannsen, Felix y Cía covers produced in that time:
Used 22 April 1913 from Mexico City to New York City
"J.F.&Co." perfin on 5 centavos Miguel Hildalgo definitive (1910) - Scott 314
Used 4 May 1913 from Mexico City to Zacatlán. JF&Co perfin on 5 centavos Miguel Hildalgo definitive (1910) - Scott 314
The advertisement on the reverse of the cover is for dog biscuits.
Unused Self Addressed Stamped Envelope (SASE)
"JF&Co" perfins on 2 & 3 centavos definitives (1910) - Scott 311 & 312
Used 3 December 1914 from Mexico City to Hamburg, Germany
"JF&Co" perfin on 4 centavos Juan Aldama overprint (1914) - Scott 426
J.F.&Co. perfins on two of the six stamps. Perhaps W. Pohle got the envelope and perfin stamps from Johannsen Felix Co. drugstore in Mexico City. The cover is addressed to A.O. Tittmann in New York, a respected philatelist whose Sonora, Mexico Specialized Revolution Era collection was donated to the Smithsonian Postal Museum. The sender, W.Pohle, advertised in Meekels Weekly Stamp News, Vol. 30, June 17, 1916. He had a small 4 line ad, "50 Different Mexico, $2.00". The reverse of the cover advertises Tanglefoot, a sticky fly trap: "Guerra A Moscas" or War on Flies.
Here are some of the stamps which have Johannsen Felix y Cía "JF&Co" perfins: